ABSTRACT
Multiple myeloma (MM) is a clonal proliferation of abnormal plasma cells. Beginning with the use of proteasome inhibitor (PI), the treatment of MM has been significantly improved. Ixazomib is a new generation of PI, the clinical studies have shown that it has good efficacy and safety in frontline therapy, maintenance therapy and treatment of relapsed/refractory MM patients, mainly reflected in prolonging progression-free survival, low peripheral neurotoxicity and long-term medication without accumulated toxicity. This article reviews the mechanism of action, pharmacokinetics, clinical studies and adverse reactions of ixazomib, in order to provide references for the treatment of MM.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk factors of Helicobacter Pylori (Hp) infection.</p><p><b>METHODS</b>All cases and controls came from 561 cases of out-patients with stomach diseases seeking gastroscopy in the Zhejiang Province First Hospital between April and July in 2000. The tissue samples of patients were stained for Hp by the improved Warthin-Starry technique and by methylene blue stain for routine histopathology. We classified patients as cases or controls based on the detection of Hp or not. Before gastroscopy, a questionnaire on lifestyle and health condition of was administered to patients by the interviewers.</p><p><b>RESULTS</b>The overall prevalence of Hp infection was 50.21% and the risk factors of Hp infection were significantly different between males and females. As for males, the duration of daily heavy physical activities, numbers of siblings in the household, family history of oliver disease, preference of spicy food and smoking were the risk factors for Hp infection. However, preference of beans and bean products, drinking well water, drinking tea, eating regularly and good education appears to decrease the prevalence of infection. As for females, consumption of caffeine contained beverages seemed to increase risk for infection. By analyzing with unconditional Logistic Regression Model in male and female groups combined, it brought to light that intake of egg and peppery food were the risk factors of infection, and intake of beans and drinking tea were the protective factors.</p><p><b>CONCLUSION</b>Consumption of beans and drinking tea must be advocated and the consumption of spicy food should be discouraged.</p>
Subject(s)
Female , Humans , Male , Case-Control Studies , China , Helicobacter Infections , Epidemiology , Helicobacter pylori , Outpatients , Risk Factors , Stomach Diseases , EpidemiologyABSTRACT
Tie effects of L-ascorbate 2-sulfate(AAS) on fatty liver and hyperli-pemia of rat and guinea pigs induced by various treatments were studied. The results showed that AAS lowered cholesterol and total lipid levels in the serum and liver of rats fed diets supplemented with lard and cholesterol, while ascorbic acid had no obvious effect. In guinea pigs, AAS not only lowered serum lipid values and liver cholesterol, triglyceride and total lipid levels of DDT treated animals, but also prevented from decline of body weights of these animals. It also had the same effects to lower the serum and liver lipid values of those animals fed pentabarbital or high lipid diet.Remarkable increases of the lipid peroxide value of animals given high doses of AsA were observed, but no such effect occurred in those fed AAS.